Modified Nucleosides
2'-Deoxy-2-thiouridine
Quick view. We supply 2'-Deoxy-2-thiouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 35059-12-2. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2'-Deoxy-2-thiouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12N2O4S; molecular weight 244.27).
2'-Deoxy-2-thiouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-Deoxy-2-thiouridine, reported solubility: Methanol (Slightly), Water (Slightly). Storage: Hygroscopic, Refrigerator, under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- 2-Thiodeoxyuridine
- 2-Thio 2'-Deoxyuridine
- Uridine, 2'-deoxy-2-thio-
- 2’-Deoxy-2-thiouridine, anticancer agent
- 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-2-thiouracil
- 1-(2'-deoxy-β-D-erythro-ribofuranosyl)-2-thiouracil
Useful catalog search terms
- CAS 35059-12-2
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| Melting point | 199-202 °C (decomp)(Solv: ethanol (64-17-5)) |
|---|---|
| Density | 1.59±0.1 g/cm3(Predicted) |
| pKa | 7.04±0.20(Predicted) |
| Form | Solid |
| Color | White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Related products
(S)-cEt-rA
Modified Nucleosides · CAS: 1197033-34-3
BX-OP-0069S-Adenosylmethionine (SAM)
Modified Nucleosides · CAS: 485-80-3
BX-MN-0185(R-/S-) 5-Carbamoylhydroxy methyluridine
Modified Nucleosides · CAS: N/A
BX-MN-0186(R-/S-)5-(1-Hydroxy)(methoxycarbonyl)methyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0187(R-/S-)5-Carboxyhydroxymethyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0719(R)-N-(2,3-dihydro-1H-indenyl)adenosine
Modified Nucleosides · CAS: 96392-15-3
Frequently asked questions
Can the package size for 2'-Deoxy-2-thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0488 and CAS 35059-12-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-Deoxy-2-thiouridine or the named structural feature represented by this product.
- Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction. (2019)
- Synthesis and photochemical behavior of the tetrazolo tautomer of 2-azido-4-pyrimidinone-2'-deoxyriboside. (2011)
- Enzymatic synthesis and phosphorolysis of 4(2)-thioxo- and 6(5)-azapyrimidine nucleosides by E. coli nucleoside phosphorylases. (2016)
- Desulfurization of 2-thiouracil nucleosides: conformational studies of 4-pyrimidinone nucleosides. (2011)
- Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. (2007)