2'-O-Me Nucleosides
2'-O-Me-2-NH₂-rA
Quick view. We supply 2'-O-Me-2-NH₂-rA as a 2'-O-methyl nucleoside for modified RNA monomer, nucleotide and analytical standard workflows. CAS 80791-87-3. Catalog target purity: ≥98%.
Product profile
2'-O-Me-2-NH₂-rA is classified as nucleoside or protected nucleoside intermediate (Formula C11H16N6O4; molecular weight 296.28).
2'-O-Me-2-NH₂-rA can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-Me-2-NH₂-rA, form: Powder.
Names and search terms
Confirmed or normalized name variants
- 2'-O-METHYL-2-AMINOADENOSINE
- 2-AMINO-2'-O-METHYLADENOSINE
- 2-Amino-N2-O-methyladenosine
- Adenosine, 2-amino-2'-O-methyl-
- 2-Amino-2'-O-methyl-D-adenosine
- 2,6-Diamino-9-(2'-O-methyl-b-D-ribofuranosyl)purine
- (2R,3R,4R,5R)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol
Useful catalog search terms
- CAS 80791-87-3
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| Melting point | 121-122℃ |
| Boiling point | 733.2±70.0 °C(Predicted) |
| Density | 1.98 |
| pKa | 13.12±0.70(Predicted) |
| Form | Powder |
| Color | White to Off-white |
| InChI | InChI=1S/C11H16N6O4/c1-20-7-6(19)4(2-18)21-10(7)17-3-14-5-8(12)15-11(13)16-9(5)17/h3-4,6-7,10,18-19H,2H2,1H3,(H4,12,13,15,16)/t4-,6-,7-,10-/m1/s |
| InChIKey | JLWUWXCKSOIFPS-KQYNXXCUSA-N |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)N)N)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-2-NH₂-rA or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Me-2-NH₂-rA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0002 and CAS 80791-87-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.