2'-O-Me Nucleosides
2'-O-Me-rG
Quick view. We supply 2'-O-Me-rG as a 2'-O-methyl guanosine nucleoside for modified RNA and oligonucleotide monomer synthesis. CAS 2140-71-8. Catalog target purity: Specification on request.
Product profile
2'-O-Me-rG is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N5O5; molecular weight 297.27).
2'-O-Me-rG can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-Me-rG, reported solubility: Aqueous Base (Slightly), DMSO (Slightly),. Storage: Keep in dark place,Inert atmosphere,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-O-METHYLGUANOSINE
- 2'-O-Methyl-D-guanosine
Useful catalog search terms
- CAS 2140-71-8
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| Melting point | 227-231°C (dec.) |
| Density | 1.98±0.1 g/cm3(Predicted) |
| Form | Powder |
| Color | White to Off-white |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OC)[C@@H]1O |
| InChI | InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s |
| InChIKey | OVYNGSFVYRPRCG-KQYNXXCUSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rG or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Me-rG be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0178 and CAS 2140-71-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.