Protected Nucleosides
2'-O-TBDMS-uridine
Quick view. We supply 2'-O-TBDMS-uridine as a silyl-protected ribonucleoside intermediate for RNA monomer and specialty nucleoside synthesis. CAS 54925-71-2. Catalog target purity: Specification on request.
Product profile
2'-O-TBDMS-uridine is classified as nucleoside or protected nucleoside intermediate (Formula C15H26N2O6Si; molecular weight 358.46).
2'-O-TBDMS-uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-TBDMS-uridine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 2'-TBDMS-rU
- 2'-O-TBDMS-Ur
- 2'-O-(tert-butyldiMethylsilyl)uridine
- Uridine, 2'-O-[(1,1-dimethylethyl)dimethylsilyl]-
Useful catalog search terms
- CAS 54925-71-2
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection |
|---|---|
| InChI | InChI=1S/C15H26N2O6Si/c1-15(2,3)24(4,5)23-12-11(20)9(8-18)22-13(12)17-7-6-10(19)16-14(17)21/h6-7,9,11-13,18,20H,8H2,1-5H3,(H,16,19,21)/t9-,11-,12-,13-/m1/s |
| InChIKey | AYQZFVZTNUOLCQ-OJAKKHQRSA-N |
| SMILES | CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 2'-O-TBDMS-uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0255 and CAS 54925-71-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.