Modified Nucleosides
2-Thioadenosine
Quick view. We supply 2-Thioadenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 43157-50-2. Catalog target purity: Specification on request.
Product profile
2-Thioadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H13N5O4S; molecular weight 299.31).
2-Thioadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2-Thioadenosine, reported solubility: Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated). Storage: Keep in dark place,Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2-Thio-Ar
- 2,3-dihydro-2-thioxoAdenosine
- Adenosine,1,2-dihydro-2-thioxo-
- Adenosine, 2,3-dihydro-2-thioxo-
- 2-Thioadenosine (Cangrelor intermediate 1)
- 6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purine-2-thione
Useful catalog search terms
- CAS 43157-50-2
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C10H13N5O4S/c11-7-4-8(14-10(20)13-7)15(2-12-4)9-6(18)5(17)3(1-16)19-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,20)/t3-,5-,6-,9-/m1/s |
|---|---|
| InChIKey | LTESOZAUMTUKQX-UUOKFMHZSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(=NC(=S)N3)N)N=C2)[C@H](O)[C@@H]1O |
| Melting point | >178°C (dec.) |
| Boiling point | 544.5±60.0 °C(Predicted) |
| Density | 2.18±0.1 g/cm3(Predicted) |
| pKa | 8.37±0.40(Predicted) |
| Form | Solid |
| Color | Pale Yellow to Yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 2-Thioadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0535 and CAS 43157-50-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.