Cyclic Dinucleotides
3',3'-cGAMP disodium salt
Quick view. We supply 3',3'-cGAMP disodium salt for comparative STING signaling and cyclic GMP-AMP assay development. CAS 2407516-83-8. Catalog target purity: ≥98%.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
3',3'-cGAMP disodium salt is classified as cyclic dinucleotide second messenger or analog (Formula C20H25N10NaO13P2; molecular weight 698.41).
3',3'-cGAMP disodium salt — cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
For 3',3'-cGAMP disodium salt, reported solubility: Water: 10 mM. Storage: Store at -20°C.
Names and search terms
Confirmed or normalized name variants
- cGAMP disodium
- 3'3'-cGAMP disodium
- 3',3'-cyclic GMP-AMP disodium
Useful catalog search terms
- CAS 2407516-83-8
- Cyclic Dinucleotides
- Cyclic dinucleotide second messenger or analog
- cyclic dinucleotide topology
Physicochemical data
| Key chemistry motifs | cyclic dinucleotide topology |
|---|---|
| Linkage | Two 3'-5' phosphodiester linkages |
| Counterion | Disodium |
| Supply form | Dry salt |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 3',3'-cGAMP disodium salt can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Defined linkage isomers and counterion forms allow controlled comparisons across cyclic-dinucleotide assay conditions.
Method limitations
- Activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
These points describe 3',3'-cGAMP disodium salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2',3'-cGAMP
Cyclic Dinucleotides · CAS: 1441190-66-4
BX-CDN-00022',3'-cGAMP sodium salt
Cyclic Dinucleotides · CAS: 2734858-36-5
BX-CDN-00032'3'-c-di-AM(PS)2 (Rp,Rp) disodium salt
Cyclic Dinucleotides · CAS: 1638750-95-4
BX-CDN-00043',3'-cGAMP
Cyclic Dinucleotides · CAS: 849214-04-6
BX-CDN-00052'3'-c-di-AM(PS)2 (Rp,Rp) ammonium salt
Cyclic Dinucleotides · CAS: 1638750-96-5
BX-CDN-00062'3'-c-di-AM(PS)2 (Rp,Rp)
Cyclic Dinucleotides · CAS: 1638241-89-0
Frequently asked questions
Can the package size for 3',3'-cGAMP disodium salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CDN-0009 and CAS 2407516-83-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cyclic Dinucleotides product family and its named chemistry.
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic G(2',5')pA(3',5')p is the metazoan second messenger produced by cGAS
- STING is a direct innate immune sensor of cyclic di-GMP
- Cyclic di-AMP secreted by Listeria monocytogenes activates a host type I interferon response