TIPDS-protected Nucleosides
3',5'-O-TIPDS-rC(Ac)
Quick view. We supply 3',5'-O-TIPDS-rC(Ac) as an acetyl-protected cytidine TIPDS intermediate for selective 2'-functionalization in RNA nucleoside synthesis. CAS 85335-73-5. Catalog target purity: ≥95%.
Product profile
3',5'-O-TIPDS-rC(Ac) is classified as nucleoside or protected nucleoside intermediate (Formula C23H41N3O7Si; molecular weight 527.76).
3',5'-O-TIPDS-rC(Ac) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3',5'-O-TIPDS-rC(Ac), storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 3,5-TIPS-N-Ac-C
- 3',5'-TIPS-Ac-rC
- N4-Ac-3',5'-TIPDS-Cr
- 3',5'-TIPS-N-Ac-Cytidine
- N4-Acetyl-3',5'-O-TIPDS
- cytidine
- 5',3'-tetraisopropyl disiloxane-ribocytidine(N-acetyl)
- N4-acetyl-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-cytidine
Useful catalog search terms
- CAS 85335-73-5
- Nucleoside or protected nucleoside intermediate
- TIPDS protection
- TIPDS-protected Nucleosides
Physicochemical data
| Key chemistry motifs | TIPDS protection |
|---|---|
| Density | 1.24±0.1 g/cm3(Predicted) |
| pKa | 10.22±0.20(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Related products
3',5'-O-TIPDS-2'-Spirocyclopropyl-U
TIPDS-protected Nucleosides · CAS: 140902-00-7
BX-PN-00143',5'-O-TIPDS-rA(Ac)
TIPDS-protected Nucleosides · CAS: N/A
BX-PN-00163',5'-O-TIPDS-rG(Pac)
TIPDS-protected Nucleosides · CAS: 131474-72-1
BX-PN-00173',5'-O-TIPDS-rU
TIPDS-protected Nucleosides · CAS: 69304-38-7
Frequently asked questions
Can the package size for 3',5'-O-TIPDS-rC(Ac) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0015 and CAS 85335-73-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the TIPDS-protected Nucleosides product family and its named chemistry.