TIPDS-protected Nucleosides
3',5'-O-TIPDS-rG(Pac)
Quick view. We supply 3',5'-O-TIPDS-rG(Pac) as a phenoxyacetyl-protected guanosine TIPDS intermediate for modified RNA monomer synthesis. CAS 131474-72-1. Catalog target purity: ≥98%.
Product profile
3',5'-O-TIPDS-rG(Pac) is classified as nucleoside or protected nucleoside intermediate (Formula C30H45N5O8Si; molecular weight 659.88).
3',5'-O-TIPDS-rG(Pac) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3',5'-O-TIPDS-rG(Pac), confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 3',5'-TIPS-PAc-rG
- 3',5'-TIPS-N-PAC-G
- N2-Pac-3',5'-TIPDS-Gr
- 3',5'-TIPS-N-PAc-Guanosine
- N2-Pac-3',5'-O-TIPDSguanosine
- 5',3'-tetraisopropyl disiloxane-riboguanosine(N-PAC)
- N2-Pac-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-guanosine
- N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine
Useful catalog search terms
- CAS 131474-72-1
- Nucleoside or protected nucleoside intermediate
- TIPDS protection
- TIPDS-protected Nucleosides
Physicochemical data
| Key chemistry motifs | TIPDS protection |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| pKa | 8.83±0.20(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Related products
3',5'-O-TIPDS-2'-Spirocyclopropyl-U
TIPDS-protected Nucleosides · CAS: 140902-00-7
BX-PN-00143',5'-O-TIPDS-rA(Ac)
TIPDS-protected Nucleosides · CAS: N/A
BX-PN-00153',5'-O-TIPDS-rC(Ac)
TIPDS-protected Nucleosides · CAS: 85335-73-5
BX-PN-00173',5'-O-TIPDS-rU
TIPDS-protected Nucleosides · CAS: 69304-38-7
Frequently asked questions
Can the package size for 3',5'-O-TIPDS-rG(Pac) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0016 and CAS 131474-72-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the TIPDS-protected Nucleosides product family and its named chemistry.