Amino-modified Nucleosides
3'-beta-Azido-2',3'-dideoxyuridine
Quick view. We supply 3'-beta-Azido-2',3'-dideoxyuridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 101039-96-7. Catalog target purity: Specification on request.
Product profile
3'-beta-Azido-2',3'-dideoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11N5O4; molecular weight 253.22).
3'-beta-Azido-2',3'-dideoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-beta-Azido-2',3'-dideoxyuridine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- AZddU (threo)
- 3’-β-Azido-2’,3’-dideoxyuridine
- 1-(3-Azido-2,3-dideoxy-b-D-threo-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione
- 2,4(1H,3H)-Pyrimidinedione,1-(3-azido-2,3-dideoxy-b-D-threo-pentofuranosyl)-
Useful catalog search terms
- CAS 101039-96-7
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C9H11N5O4/c10-13-12-5-3-8(18-6(5)4-15)14-2-1-7(16)11-9(14)17/h1-2,5-6,8,15H,3-4H2,(H,11,16,17)/t5-,6-,8-/m1/s |
| InChIKey | ZSNNBSPEFVIUDS-ATRFCDNQSA-N |
| SMILES | [N-]=[N+]=N[C@@H]1C[C@H](n2ccc(O)nc2=O)O[C@@H]1CO |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 3'-beta-Azido-2',3'-dideoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-beta-Azido-2',3'-dideoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0134 and CAS 101039-96-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 3'-beta-Azido-2',3'-dideoxyuridine or the named structural feature represented by this product.