Modified Nucleosides
3'-O-(2-Methoxyethyl)-2-thiouridine
Quick view. We supply 3'-O-(2-Methoxyethyl)-2-thiouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 647839-20-1. Catalog target purity: Specification on request.
Product profile
3'-O-(2-Methoxyethyl)-2-thiouridine is classified as nucleoside or protected nucleoside intermediate (Formula C12H18N2O6S; molecular weight 318.35).
3'-O-(2-Methoxyethyl)-2-thiouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-(2-Methoxyethyl)-2-thiouridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- CTK2A3325
- Uridine, 2'-O-(2-methoxyethyl)-2-thio- (9CI)
Useful catalog search terms
- CAS 647839-20-1
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| InChI | InChI=1S/C12H18N2O6S/c1-18-4-5-19-10-9(17)7(6-15)20-11(10)14-3-2-8(16)13-12(14)21/h2-3,7,9-11,15,17H,4-6H2,1H3,(H,13,16,21)/t7-,9-,10-,11-/m1/s |
| InChIKey | BSYHPITVITYUAG-QCNRFFRDSA-N |
| SMILES | COCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=S)CO)O |
| Density | 1.48±0.1 g/cm3(Predicted) |
| pKa | 6.97±0.20(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-(2-Methoxyethyl)-2-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-(2-Methoxyethyl)-2-thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0804 and CAS 647839-20-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.