Cap Analogs
3'-O-Me-m7G(5')ppp(5')A
Quick view. We supply 3'-O-Me-m7G(5')ppp(5')A as an anti-reverse cap analog for capped RNA and in-vitro transcription research. A public CAS number is not assigned for this exact form. Catalog target purity: ≥99%.
Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
3'-O-Me-m7G(5')ppp(5')A is classified as rna cap analog or cap-related nucleotide.
3'-O-Me-m7G(5')ppp(5')A — This cap analog can support capped RNA preparation, cap-orientation studies and IVT method development.
For 3'-O-Me-m7G(5')ppp(5')A, storage: Store sealed and dry; protect from moisture and follow the lot-specific CoA for temperature and hold time.
Names and search terms
Confirmed or normalized name variants
- 3'-O-methyl-m7GpppA
- 3'-O-Me m7GpppA cap analog
Useful catalog search terms
- RNA cap analog or cap-related nucleotide
- Cap Analogs
Physicochemical data
| Purity basis | Research-grade target; the lot-specific CoA reports the release result and analytical method. |
|---|---|
| Cap modification | 3'-O-methyl on m7G |
| Supply form | Dry research material |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 3'-O-Me-m7G(5')ppp(5')A can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
- Cap analog selection can influence capping efficiency, orientation and downstream translation-related performance.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
- Capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
These points describe 3'-O-Me-m7G(5')ppp(5')A or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
ARCA
Cap Analogs · CAS: 400806-46-4
BX-CA-0002CAP A(5')ppp(5')(2'-OMeA)pG Ammonium Salt
Cap Analogs · CAS: N/A
BX-CA-0003CAP 4 m7G(UNA)(5')ppp(5')(2'OMeA)pG Ammonium Salt
Cap Analogs · CAS: N/A
BX-CA-0004CAP 5 m7G(5')vppp(5')(2'OMeA)pG Ammonium Salt
Cap Analogs · CAS: 3038327-80-6
BX-CA-0005CAP 6 m7G(LNA)(5')ppp(5')(2'OMeA)pG Ammonium Salt
Cap Analogs · CAS: 2645354-92-1
BX-CA-0006CAP 7 m7G(HNA)(5')ppp(5')(2'OMeA)pG Ammonium Salt
Cap Analogs · CAS: N/A
Frequently asked questions
Can the package size for 3'-O-Me-m7G(5')ppp(5')A be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-GSS-0005, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cap Analogs product family and its named chemistry.