Modified Nucleosides
3'-O-Methylcytidine
Quick view. We supply 3'-O-Methylcytidine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 20594-00-7. Catalog target purity: Specification on request.
Product profile
3'-O-Methylcytidine is classified as nucleoside or protected nucleoside intermediate (Formula C10H15N3O5; molecular weight 257.24).
3'-O-Methylcytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-Methylcytidine, form: Solid.
Names and search terms
Confirmed or normalized name variants
- 3'-OMe-Cytidine
- Cytidine, 3'-O-methyl-
- 3'-(O-METHYL)CYTIDINE
- 3'-(O-METHYL)CYTIDINE USP/EP/BP
- 4-amino-1-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidin-2-one
Useful catalog search terms
- CAS 20594-00-7
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C10H15N3O5/c1-17-8-5(4-14)18-9(7(8)15)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s |
|---|---|
| InChIKey | RZJCFLSPBDUNDH-ZOQUXTDFSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](O)[C@@H]1OC |
| Boiling point | 506.0±60.0 °C(Predicted) |
| Density | 1.68±0.1 g/cm3(Predicted) |
| pKa | 13.34±0.70(Predicted) |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 3'-O-Methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-Methylcytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0790 and CAS 20594-00-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.