Modified Nucleosides
3'-O-(t-Butyldiphenylsilyl)thymidine
Quick view. We supply 3'-O-(t-Butyldiphenylsilyl)thymidine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 83467-48-5. Catalog target purity: Specification on request.
Product profile
3'-O-(t-Butyldiphenylsilyl)thymidine is classified as nucleoside or protected nucleoside intermediate (Formula C26H32N2O5Si; molecular weight 480.63).
3'-O-(t-Butyldiphenylsilyl)thymidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-(t-Butyldiphenylsilyl)thymidine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- Thymidine, 3′-O-[(1,1-dimethylethyl)diphenylsilyl]-
- 3’-O-tert-Butyldiphenylsilylthymidine
- 2'-Deoxy-3'-O-[(2-methyl-2-propanyl)(diphenyl)silyl]-3,4-dihydrot hymidine
Useful catalog search terms
- CAS 83467-48-5
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C26H34N2O5Si/c1-18-16-28(25(31)27-24(18)30)23-15-21(22(17-29)32-23)33-34(26(2,3)4,19-11-7-5-8-12-19)20-13-9-6-10-14-20/h5-14,18,21-23,29H,15-17H2,1-4H3,(H,27,30,31)/t18?,21-,22+,23+/m0/s |
|---|---|
| InChIKey | KYIOWQKIGDBICI-KMWPLCEJSA-N |
| SMILES | CC1CN([C@H]2C[C@H](O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)[C@@H](CO)O2)C(=O)NC1=O |
| Melting point | 68-72 °C |
| Density | 1.23±0.1 g/cm3(Predicted) |
| pKa | 9.55±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 3'-O-(t-Butyldiphenylsilyl)thymidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0691 and CAS 83467-48-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.