Protected Nucleosides
3'-O-TBDMS-adenosine
Quick view. We supply 3'-O-TBDMS-adenosine as a silyl-protected ribonucleoside intermediate for RNA monomer and specialty nucleoside synthesis. CAS 69504-14-9. Catalog target purity: Specification on request.
Product profile
3'-O-TBDMS-adenosine is classified as nucleoside or protected nucleoside intermediate (Formula C16H27N5O4Si; molecular weight 381.5).
3'-O-TBDMS-adenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-TBDMS-adenosine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- PUBCHEM_70700899
- 3'-O-t-ButyldiMethylsilyl adenosine
- 3'-O-tert-Butyldimethylsilyladenosine
- Adenosine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]- (9CI)
Useful catalog search terms
- CAS 69504-14-9
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection |
|---|---|
| InChI | InChI=1S/C16H26N5O4Si/c1-15(2,3)25-11-9(6-22)24-16(12(11)23,26(4)5)21-8-20-10-13(17)18-7-19-14(10)21/h7-9,11-12,22-23H,6H2,1-5H3,(H2,17,18,19)/t9-,11-,12-,16+/m1/s |
| InChIKey | HVBGMSXQQXPYDT-JRFJBVBDSA-N |
| SMILES | CC(C)(C)O[C@@H]1[C@H](O[C@]([C@@H]1O)(N2C=NC3=C(N=CN=C32)N)[Si](C)C)CO |
| Boiling point | 572.2±60.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| pKa | 12.98±0.70(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 3'-O-TBDMS-adenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0266 and CAS 69504-14-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.