Modified Nucleotides
3'-OMe-GMP
Quick view. We supply 3'-OMe-GMP as a methylated guanosine monophosphate building block for preparing 3'-O-methyl cap analogs and related imidazolide intermediates. CAS 400806-41-9. Catalog target purity: ≥95%.
Product profile
3'-OMe-GMP is classified as nucleoside monophosphate or analog (Formula C11H16N5O8P; molecular weight 377.25).
3'-OMe-GMP can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For 3'-OMe-GMP, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- 3'-O-Methyl-5'-guanylic acid
- 5'-Guanylic acid, 3'-O-methyl-
- 3'-O-methylguanosine 5'- phosphate
- 3'-O-methylguanosine 5'-monophosphate
- 3'-O-Methylguanosine 5'-(dihydrogen phosphate)
Useful catalog search terms
- CAS 400806-41-9
- Nucleoside monophosphate or analog
- Modified Nucleotides
Physicochemical data
| InChI | InChI=1S/C11H16N5O8P/c1-22-7-4(2-23-25(19,20)21)24-10(6(7)17)16-3-13-5-8(16)14-11(12)15-9(5)18/h3-4,6-7,10,17H,2H2,1H3,(H2,19,20,21)(H3,12,14,15,18)/t4-,6-,7-,10-/m1/s |
|---|---|
| InChIKey | JGYKGFFURACNNS-KQYNXXCUSA-N |
| SMILES | CO[C@H]1[C@@H](O)[C@H](n2cnc3c(O)nc(=N)[nH]c32)O[C@@H]1COP(=O)(O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 3'-OMe-GMP or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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Frequently asked questions
Can the package size for 3'-OMe-GMP be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-INTE-0014 and CAS 400806-41-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleotides product family and its named chemistry.