Modified Nucleotides
Im-3'-OMe-GMP
Quick view. We supply Im-3'-OMe-GMP as an imidazolide-activated 3'-O-methyl GMP precursor for cap analog coupling. It is used to prepare ARCA-type cap structures and related standards. CAS 1005791-93-4. Catalog target purity: Specification on request.
Product profile
Im-3'-OMe-GMP is classified as nucleoside monophosphate or analog (Formula C14H18N7O7P; molecular weight 427.31 g/mol (calculated from molecular formula)).
Im-3'-OMe-GMP can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For Im-3'-OMe-GMP, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- Guanosine, 3′-O-methyl-, 5′-(hydrogen P-1H-imidazol-1-ylphosphonate)
Useful catalog search terms
- CAS 1005791-93-4
- Nucleoside monophosphate or analog
- Modified Nucleotides
Physicochemical data
| CAS context | The listed CAS refers to the parent/free-acid identity; confirm the supplied salt or counterion in the current specification. |
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Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe Im-3'-OMe-GMP or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for Im-3'-OMe-GMP be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-INTE-0021 and CAS 1005791-93-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleotides product family and its named chemistry.