Amino-modified Nucleosides
4'-alpha-Azidouridine
Quick view. We supply 4'-alpha-Azidouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 139442-01-6. Catalog target purity: Specification on request.
Product profile
4'-alpha-Azidouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11N5O6; molecular weight 285.214).
4'-alpha-Azidouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 4'-alpha-Azidouridine, form: Solid.
Names and search terms
Confirmed or normalized name variants
- 4'-Azidouridine
- 4'-C-azidouridine
- Uridine, 4'-azido-
- Uridine, 4'-C-azido-
- 1-(4'-Azido-beta-D-ribofuranosyl)uracil
- 4’-alpha-Azidouridine, 1-(4’-Azido-beta-D-ribofuranosyl)uracil
- 1-[(2R,3R,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Useful catalog search terms
- CAS 139442-01-6
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C9H11N5O6/c10-13-12-9(3-15)6(18)5(17)7(20-9)14-2-1-4(16)11-8(14)19/h1-2,5-7,15,17-18H,3H2,(H,11,16,19)/t5-,6+,7-,9-/m1/s |
| InChIKey | FHPJZSIIXUQGQE-JVZYCSMKSA-N |
| SMILES | [N-]=[N+]=N[C@]1(CO)O[C@@H](n2ccc(O)nc2=O)[C@H](O)[C@@H]1O |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 4'-alpha-Azidouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 4'-alpha-Azidouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0143 and CAS 139442-01-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 4'-alpha-Azidouridine or the named structural feature represented by this product.