2'-F Nucleosides
5-Bromo-2'-fluoro-2'-deoxyuridine
Quick view. We supply 5-Bromo-2'-fluoro-2'-deoxyuridine as a 2'-fluoro nucleoside for modified nucleotide, amidite and nucleoside analog synthesis. CAS 55612-18-5. Catalog target purity: Specification on request.
Product profile
5-Bromo-2'-fluoro-2'-deoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H10BrFN2O5; molecular weight 325.09).
5-Bromo-2'-fluoro-2'-deoxyuridine — 5-Bromo-2'-deoxy-2'-fluorouridine is an analog of Uridine and used as a reagent in the synthesis of β-D-arabinofuranosyl and deoxyfluoro-β-D-ribofuranosyl pyrimidine nucleoside analogs which exhibit antituberculosis activity against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium in vitro.
For 5-Bromo-2'-fluoro-2'-deoxyuridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 5-Bromo-1-(2-deoxy-2-fluoropentofuranosyl)-4-hydroxypyrimidin-2(1H)-one
- Uridine, 5-bromo-2'-deoxy-2'-fluoro-
- 5-bromo-1-(2-fluoro-2-deoxyribofuranosyl)uracil
- 5-bromo-1-(2-fluoro-2-deoxy-β-D-ribofuranosyl)uracil
- 5-broMo-1-(2-fluoro-2-deoxy-b-D-ribofuranosyl)uracil
- 5-BroMo-1-(2-fluoro-2-deoxy-beta-D-ribofuranosyl) uracil
Useful catalog search terms
- CAS 55612-18-5
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| InChI | InChI=1S/C9H10BrFN2O5/c10-3-1-13(9(17)12-7(3)16)8-5(11)6(15)4(2-14)18-8/h,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5-,6-,8?/m1/s |
| InChIKey | WFOXFPXBLFRFHB-CDRSNLLMSA-N |
| SMILES | O=c1nc(O)c(Br)cn1C1O[C@H](CO)[C@@H](O)[C@H]1F |
| Density | 1.98±0.1 g/cm3(Predicted) |
| pKa | 7.73±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Bromo-2'-fluoro-2'-deoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Bromo-2'-fluoro-2'-deoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Bromo-2'-fluoro-2'-deoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0178 and CAS 55612-18-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry.