Halogenated Nucleosides
5-Chloro-2',3'-dideoxy-3'-fluorouridine
Quick view. We supply 5-Chloro-2',3'-dideoxy-3'-fluorouridine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 119644-22-3. Catalog target purity: Specification on request.
Product profile
5-Chloro-2',3'-dideoxy-3'-fluorouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H10ClFN2O4; molecular weight 264.64).
5-Chloro-2',3'-dideoxy-3'-fluorouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-Chloro-2',3'-dideoxy-3'-fluorouridine, form: Solid.
Names and search terms
Confirmed or normalized name variants
- raluridine
- FCU
- 935U-83
- FddClUrd
- DRG-0215
- BW-935U-83
- GW 274666X
- 3'-Fluoro-5-chloro-2',3'-dideoxyuridine
Useful catalog search terms
- CAS 119644-22-3
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H10ClFN2O4/c10-4-2-13(9(16)12-8(4)15)7-1-5(11)6(3-14)17-7/h,5-7,14H,1,3H2,(H,12,15,16)/t5-,6+,7+/m0/s |
|---|---|
| InChIKey | WKVDSZYIGHLONN-RRKCRQDMSA-N |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)Cl)CO)F |
| Melting point | 181 °C (decomp) |
| Density | 1.61±0.1 g/cm3(Predicted) |
| pKa | 7.73±0.10(Predicted) |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Chloro-2',3'-dideoxy-3'-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Chloro-2',3'-dideoxy-3'-fluorouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0160 and CAS 119644-22-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.