Modified Nucleosides
5-Ethynyl-2'-deoxyuridine
Quick view. We supply 5-Ethynyl-2'-deoxyuridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 61135-33-9. Catalog target purity: Specification on request.
Product profile
5-Ethynyl-2'-deoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C11H12N2O5; molecular weight 252.22).
5-Ethynyl-2'-deoxyuridine — 5-Ethynyl-2’deoxyuridine is a extensively used nucleoside analog used as a probe for DNA synthesis. However, 5-Ethynyl-2’deoxyuridine is a toxic anti-metabolite, which potentially causes DNA instabi liy, necrosis and cell-cycle arrest, therefore it is often used for short-term DNA synthesis in tissue culture and living organisms where…
For 5-Ethynyl-2'-deoxyuridine, reported solubility: Soluble in DMSO (up to 10 mg/ml). Storage: -20°C.
Names and search terms
Confirmed or normalized name variants
- EYdU
- 5-E-dU
- abs9124
- Uridine,2
- Aids072372
- 5-Ethynyl-dU
- 5-Ethynyl-durd
- 5-Ethynyl-2'-dU
Useful catalog search terms
- CAS 61135-33-9
- Nucleoside or protected nucleoside intermediate
- alkyne click handle
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | alkyne click handle |
|---|---|
| InChI | InChI=1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s |
| InChIKey | CDEURGJCGCHYFH-DJLDLDEBSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=C(C#C)C(=O)NC2=O)C[C@@H]1O |
| Melting point | 199°C(lit.) |
| Density | 1.55±0.1 g/cm3(Predicted) |
| pKa | 8.29±0.10(Predicted) |
| Form | powder |
| Color | White or off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Ethynyl-2'-deoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 5-Ethynyl-2'-deoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Ethynyl-2'-deoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0613 and CAS 61135-33-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5-Ethynyl-2'-deoxyuridine or the named structural feature represented by this product.