Halogenated Nucleosides
5'-fluoro-uridine
Quick view. We supply 5'-fluoro-uridine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 316-46-1. Catalog target purity: Specification on request.
Product profile
5'-fluoro-uridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11FN2O6; molecular weight 262.19).
5'-fluoro-uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-fluoro-uridine, reported solubility: Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming). Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 1-(3,4-DIHYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-5-FLUORO-1H-PYRIMIDINE-2,4-DIONE
- 2,4-DIHYDROXY-5-FLUORO-1-BETA-D-RIBOFURANOSYLPYRIMIDINE
- 5-FLUORO-1-(BETA-D-RIBOFURANOSYL)URACIL
- 5-FLUOROURACIL-1BETA-D-RIBOFURANOSIDE
- 5-FU
- FLUOROURIDINE
- FURD
- 5-fluoro-uridin
Useful catalog search terms
- CAS 316-46-1
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | 1S/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s |
|---|---|
| InChIKey | FHIDNBAQOFJWCA-UAKXSSHOSA-N |
| SMILES | OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(F)C(=O)NC2=O |
| Melting point | 182-184 °C |
| Density | 1.4200 (estimate) |
| pKa | 7.63±0.10(Predicted) |
| Form | Powder |
| Color | White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-fluoro-uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-fluoro-uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0223 and CAS 316-46-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.