Halogenated Nucleosides
5-Iodo-2'-O-methylcytidine
Quick view. We supply 5-Iodo-2'-O-methylcytidine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 847650-69-5. Catalog target purity: Specification on request.
Product profile
5-Iodo-2'-O-methylcytidine is classified as nucleoside or protected nucleoside intermediate (Formula C10H14IN3O5; molecular weight 383.14).
5-Iodo-2'-O-methylcytidine — 5-Iodo-2’-O-methylcytidine is a nucleoside analog (NSA) which acts a chemotherapeutic agent for the induction of neuronal differentiation.
For 5-Iodo-2'-O-methylcytidine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- Cytidine, 5-iodo-2′-O-methyl-
- 5-I-2'-O-Me-C
- 5-I-2'-O-Me-Cr
- 5-lodo-2'-O-methylcytidine
Useful catalog search terms
- CAS 847650-69-5
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- Halogenated Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| InChI | InChI=1S/C10H14IN3O5/c1-18-7-6(16)5(3-15)19-9(7)14-2-4(11)8(12)13-10(14)17/h,5-7,9,15-16H,3H2,1H3,(H2,12,13,17)/t5-,6-,7-,9-/m1/s |
| InChIKey | JQWRBXTVVLSBBM-JXOAFFINSA-N |
| SMILES | CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cc(I)c(=N)nc1O |
| Boiling point | 533.0±60.0 °C(Predicted) |
| Density | 2.24±0.1 g/cm3(Predicted) |
| pKa | 13.37±0.70(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Iodo-2'-O-methylcytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-Iodo-2'-O-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Iodo-2'-O-methylcytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0259 and CAS 847650-69-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.