Modified Nucleosides
8-Hydroxy guanosine
Quick view. We supply 8-Hydroxy guanosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 3868-31-3. Catalog target purity: Specification on request.
Product profile
8-Hydroxy guanosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H13N5O6; molecular weight 299.24).
8-Hydroxy guanosine — A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro
For 8-Hydroxy guanosine, reported solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) Water (Slightly, Heated,Sonicated). Storage: -20°C Freezer.
Names and search terms
Confirmed or normalized name variants
- 8-OHG
- 8-OXO-G
- 8-OH-GUO
- NSC 90393
- 8-Hydroxy-Gr
- 8-OXOGUANOSINE
- 8-Oxo-D-guanosine
- 7,8-dihydro-8-oxo-guanosin
Useful catalog search terms
- CAS 3868-31-3
- Nucleoside or protected nucleoside intermediate
- fluorescent label
- 8-Hydroxyguanosine
- BX-MN-0511
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | fluorescent label |
|---|---|
| SMILES | OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1c(=O)[nH]c2c1[nH]c(N)nc2=O |
| Identity note | CAS and structure correspond to 8-hydroxyguanosine; confirm hydration and salt form on the current specification. |
| InChI | InChI=1S/C10H13N5O6/c11-9-13-6-3(7(19)14-9)12-10(20)15(6)8-5(18)4(17)2(1-16)21-8/h,4-5,8,16-18H,1H2,(H,12,20)(H3,11,13,14,19)/t2-,4-,5-,8-/m1/s |
| InChIKey | FPGSEBKFEJEOSA-UMMCILCDSA-N |
| Melting point | 232-235°C |
| Density | 2.43±0.1 g/cm3(Predicted) |
| pKa | 7.75±0.20(Predicted) |
| Form | White to off-white powder. |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 8-Hydroxy guanosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Fluorescent labels enable non-radioactive detection and can reduce downstream staining or secondary-label steps.
Method limitations
- Dye-labeled nucleotides or amidites are bulkier than native monomers; incorporation efficiency, label density, photobleaching and light exposure should be controlled.
These points describe 8-Hydroxy guanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 8-Hydroxy guanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0683 and CAS 3868-31-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 8-Hydroxy guanosine or the named structural feature represented by this product.