Reverse Phosphoramidites
Abasic Phosphoramidite
Quick view. We supply Abasic Phosphoramidite as a spacer/abasic-site amidite used to introduce non-nucleobasic residues into oligonucleotides. CAS 129821-76-7. Catalog target purity: ≥98%.
Product profile
Abasic Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C35H45N2O6P; molecular weight 620.72).
dSPACER is a compound for the phosphoramidite synthesis of oligonucleotides and the creation of the abasic step in the oligonucleotide sequence.Abasic phosphoramidites are used in DNA and oligonucleotide synthesis.
For Abasic Phosphoramidite, form: Oil.
Names and search terms
Confirmed or normalized name variants
- dSPACER
- DSPACER CEP
- 2'-Dideoxy-5'-O-DMT-ribose 3'-CE phosphoraMidite
- 1,2-Dideoxy-5'-O-DMT-D-ribose 3'-CE phosphoramidite
- 1',2'-Dideoxy-5'-O-DMT-ribose 3'-CE phosphoramidite
- 2'-Dideoxy-5'-O-DMT-ribose 3'-CE phosphoraMidite
- 5'-O-(4,4'-dimethoxytrityl)-1,2-dideoxyribose-3-CE-Phosphoramidite
Useful catalog search terms
- CAS 129821-76-7
- Protected oligonucleotide phosphoramidite building block
- phosphoramidite coupling group
- Reverse Phosphoramidites
Physicochemical data
| Key chemistry motifs | phosphoramidite coupling group |
|---|---|
| Boiling point | 658.6±55.0 °C(Predicted) |
| Form | Oil |
| SMILES | P(OCCC#N)(N(C(C)C)C(C)C)O[C@H]1CCO[C@@H]1COC(C1C=CC=CC=1)(C1=CC=C(C=C1)OC)C1C=CC(=CC=1)OC |&1:14,18,r| |
| InChIKey | XZGSDLJMHWJDHL-DQCWULFNNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Abasic Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
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Frequently asked questions
Can the package size for Abasic Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-RP-0009 and CAS 129821-76-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry.