RNA (2'-O-TBDMS) Phosphoramidites
DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite introduces N1-methylpseudouridine into synthetic RNA. CAS 875302-45-7. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C46H63N4O9PSi; molecular weight 875.09).
DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite — N1-Methylpseudouridine CEP is a modified ribonucleoside analogue suitable for incorporating into small interfering RNA (SiRNA) to enhance RNA stability in biological applications such as gene silencing.
For DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite, form: Solid.
Names and search terms
Confirmed or normalized name variants
- N1-Methylpseudouridine CEP
- DMT-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite
- DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-2-cyanoethyl phosphoramidite
Useful catalog search terms
- CAS 875302-45-7
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- TBDMS protection
- phosphoramidite coupling group
- RNA (2'-O-TBDMS) Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; TBDMS protection; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to off-white |
| SMILES | C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@H]1O[C@@H](C2=CN(C)C(=O)NC2=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C |&1:25,27,37,46,r| |
| InChIKey | ZDZLHJPETUXZJT-ZEONIDOHNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-R2OT-0020 and CAS 875302-45-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite or the named structural feature represented by this product.