RNA (2'-O-TBDMS) Phosphoramidites
DMTr-2'-O-TBDMS-rC(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-TBDMS-rC(Bz)-3'-CE-Phosphoramidite as the DMTr/CE form of Bz-protected cytidine for RNA oligo synthesis. CAS 118380-84-0. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-TBDMS-rC(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C52H66N5O9PSi; molecular weight 964.17).
DMTr-2'-O-TBDMS-rC(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For DMTr-2'-O-TBDMS-rC(Bz)-3'-CE-Phosphoramidite, storage: Sealed in dry,2-8°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- Bz-rC Phosphoramidite
- 5'-DMT-2'-TBDMS-N4-Bz-rC phosphoramidite
- N-blocked-5'-O-DMT-2'-O-TBDMS CED cytidine phosphoramidite
- N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine 3'-CE phosphoramidite
- DMT-2'-O-TBDMS-rC(Bz)-3'-CE-Phosphoramidite
- 2'-O-TBDMS-rC(Bz) Phosphoramidite
- BX-R2OT-0014
Useful catalog search terms
- CAS 118380-84-0
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- TBDMS protection
- phosphoramidite coupling group
- RNA (2'-O-TBDMS) Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; TBDMS protection; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to off-white |
| InChIKey | VWNXEDLLHIFAOL-KVTPLOKXNA-N |
| InChI | InChI=1S/C52H66N5O9PSi/c1-36(2)57(37(3)4)67(63-34-18-32-53)65-46-44(35-62-52(39-21-16-13-17-22-39,40-23-27-42(60-8)28-24-40)41-25-29-43(61-9)30-26-41)64-49(47(46)66-68(10,11)51(5,6)7)56-33-31-45(55-50(56)59)54-48(58)38-19-14-12-15-20-38/h12-17,19-31,33,36-37,44,46-47,49H,18,34-35H2,1-11H3,(H,54,55,58,59)/t44-,46-,47-,49-,67?/m1/s |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(=NC(=O)c4ccccc4)nc3O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Bz-rC Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
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Frequently asked questions
Can the package size for DMTr-2'-O-TBDMS-rC(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-R2OT-0018 and CAS 118380-84-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the RNA (2'-O-TBDMS) Phosphoramidites product family and its named chemistry.