GalNAc
GalNAc-L96-Succinate
Quick view. We supply GalNAc-L96-Succinate as a carboxyl-functional L96 GalNAc derivative for preparing supports and oligonucleotide conjugates. CAS 1159408-61-3. Catalog target purity: Specification on request.
Product profile
GalNAc-L96-Succinate is classified as galnac ligand, linker or conjugation intermediate (Formula C121 H179 N11 O45; molecular weight 2507.8).
GalNAc-L96-Succinate can be evaluated in ligand, linker and conjugation-route development for oligonucleotide delivery research.
For GalNAc-L96-Succinate, reported solubility: DMSO: Sparingly soluble: 1-10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml.
Names and search terms
Confirmed or normalized name variants
- L-96
- GalNAc-L96-SA
- 4-(((3R,5S)-1-(1-(((2R,3R..
- BX-GALN-0015
- GalNAc-L96
- BX-GALN-0038
Useful catalog search terms
- CAS 1159408-61-3
- GalNAc ligand, linker or conjugation intermediate
- GalNAc ligand motif
- succinate linker
- GalNAc
Physicochemical data
| Key chemistry motifs | GalNAc ligand motif; succinate linker |
|---|---|
| Boiling point | 1889.4±65.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| pKa | 4.39±0.17(Predicted) |
| InChIKey | XKEQVRGRWUKTIZ-GKBCKKAWNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- GalNAc-L96 free base is a triantennary GalNAc ligand that can be used for the synthesis of GalNAc-siRNA. GalNAc is a ligand of ASGPR (asialoglycoprotein receptor).
- Typical studies compare linker length, valency, attachment chemistry, purification strategy and analytical identity.
- The material may also support conjugate-reference or impurity-standard preparation.
Product-specific evaluation notes
Potential advantages
- A defined GalNAc intermediate helps decouple ligand-linker optimization from sequence optimization.
Method limitations
- In-vitro affinity and in-vivo delivery behavior may diverge; valency, linker length and conjugation site need empirical confirmation.
These points describe GalNAc-L96-Succinate or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for GalNAc-L96-Succinate be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-GALN-0026 and CAS 1159408-61-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the GalNAc product family and its named chemistry.