Modified Nucleosides
N6-Methyladenosine
Quick view. We supply N6-Methyladenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 1867-73-8. Catalog target purity: Specification on request.
Product profile
N6-Methyladenosine is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N5O4; molecular weight 281.27).
N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser…
For N6-Methyladenosine, reported solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated). Storage: Keep in dark place,Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- N-methyladenosine
- CS-1297
- N6-Me-A
- N6-Me-rA
- NSC-29409
- Adenosine, N-methyl-
- 6-Methylaminopurinosine
- N6-methyladenosine (m6A)
Useful catalog search terms
- CAS 1867-73-8
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C11H15N5O4/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14)/t5-,7-,8-,11-/m1/s |
|---|---|
| InChIKey | VQAYFKKCNSOZKM-IOSLPCCCSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NC)N=C2)[C@H](O)[C@@H]1O |
| Melting point | 172 °C |
| Boiling point | 649.1±65.0 °C(Predicted) |
| Density | 1.85±0.1 g/cm3(Predicted) |
| pKa | 13.12±0.70(Predicted) |
| Form | Powder |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- N6-Methyladenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for N6-Methyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0299 and CAS 1867-73-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.