2'-FANA Nucleosides
2'-Deoxy-2'-fluoro-5-methyl-4'-thio-beta-D-arabinouridine
Quick view. A beta-D-arabino uridine analogue bearing 2'-fluoro, 4'-thio and 5-methyl modifications, CAS 135123-34-1. CAS 135123-34-1. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-Deoxy-2'-fluoro-5-methyl-4'-thio-beta-D-arabinouridine is classified as 2'-fana nucleosides (Formula C10H13FN2O4S; molecular weight 276.28).
2'-Deoxy-2'-fluoro-5-methyl-4'-thio-beta-D-arabinouridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-beta-D-arabinouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- CAS 135123-34-1
- PubChem CID 11608809
- beta-D-arabino 2'-fluoro 4'-thio nucleoside
Physicochemical data
| PubChem CID | 11608809 |
|---|---|
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@H]([C@@H]([C@H](S2)CO)O)F |
| Sugar configuration | beta-D-Arabino |
| Sugar substitutions | 2'-fluoro; 4'-thio |
| Nucleobase | 5-Methyluracil |
| InChIKey | RCDAZGNPWLZONT-JVZYCSMKSA-N |
| InChI | InChI=1S/C10H13FN2O4S/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-beta-D-arabinouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-beta-D-arabinouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FAN-0017 and CAS 135123-34-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
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