BX LAB TECHNOLOGY PLATFORMS
Technology platforms for nucleic-acid chemistry and custom research materials
BX Lab makes the building blocks oligonucleotides are assembled from, the reagents that assemble them, and the standards used to check the result came out right. Each platform below lists what it covers and how many products in the catalog sit behind it, so the claims can be checked against the catalog rather than taken on trust.
Platform overview
Stereochemical control
Phosphorothioate stereochemistry is where oligonucleotide chemistry gets hard, and most suppliers stop at the racemate. We make the chiral reagents the stereocontrolled route runs on, and the resolved standards you need to prove the route worked.
- (D)- and (L)-DPSE and PSM amidites across 2′-F, 2′-O-Me, 2′-O-MOE and 2′-O-TBDMS series, plus selected DNA chemistry (26 in catalog)
- Resolved Rp and Sp NTPαS diastereomers for method validation (7) — a supplier without stereocontrol cannot make these
- 2′3′-c-di-AM(PS)₂ (Rp,Rp) supplied with defined phosphorothioate configuration
- See the catalog-derived D/L pair matrix below
Nucleoside & nucleotide chemistry
Design and preparation of protected nucleosides, modified nucleotides, NTP salts, cap-related materials and analytical standards for RNA and molecular biology workflows.
- Modified base and sugar analogs
- Triphosphate and nucleotide salt planning
- Salt form, water content and purity control
- Analytical comparison materials
Oligonucleotide building-block platform
Research-use phosphoramidites, succinates, solid-support related intermediates and specialty monomers for DNA, RNA and chemically modified oligonucleotide synthesis.
- 2′-modified RNA monomers: 2′-F, 2′-O-Me, 2′-O-MOE, 2′-O-C16 and 2′-O-C22
- Locked and bridged monomers — LNA and cEt (17)
- Reverse amidites for 5′→3′ synthesis (15)
- Morpholino (PMO) monomers (17)
- Deprotection and compatibility review
Sulfurization & activation chemistry
Sulfurizing reagents, coupling activators and process support for phosphorothioate and solid-phase oligonucleotide synthesis workflows.
- DDTT, PADS, Beaucage-type and related sulfurizing reagents
- DCI, BTT, ETT and related activator selection
- Solubility and reaction-rate comparison
- Scale and handling assessment
GalNAc & conjugation chemistry
Ligands, linkers, clusters and conjugation-ready intermediates for delivery, labeling and functionalized oligonucleotide research.
- GalNAc ligand/linker intermediates
- Azide, alkyne, amino, thiol and maleimide handles
- PEG and spacer design
- Dye, affinity tag and payload conjugation support
Cyclic dinucleotides
- 2′,3′- and 3′,3′-cGAMP, c-di-AMP, c-di-GMP, cAIMP
- Free acid, disodium and ammonium forms of 2′3′-c-di-AM(PS)₂ (Rp,Rp) are linked below
- Each salt form is a separate catalog record; counterion and exact supplied form matter for calculations
- Made on the same amidite chemistry as the rest of the catalog
Glycochemistry
- Sugar nucleotides: UDP-Glc, UDP-Gal, UDP-GlcNAc, UDP-GalNAc, UDP-GlcA, GDP-L-Fuc, CMP-Neu5Ac
- Defined β1→3, β1→4 and α1→3/α1→4 linked di- and oligosaccharides
- GalNAz, Ac₄GalNAz and azido sugars for click chemistry
- Protected ribofuranose building blocks feeding the nucleoside routes above
mRNA raw-material platform
Materials and technical support for mRNA research workflows including cap analogs, modified nucleotides, nucleotide intermediates and analytical standards.
- Cap analog and modified NTP selection
- IVT material planning
- Research-use raw material sourcing
- Application-specific specification review
Reference, impurity & analytical standards
Defined standards to support method development, impurity identification, forced-degradation studies and lot-to-lot analytical comparison.
- Resolved Rp/Sp NTPαS diastereomers (7) for stereochemical method validation
- Known impurity preparation
- Process marker synthesis
- LC-MS/HPLC/NMR support package
- Stability-indicating method inputs
Custom synthesis & route development
Feasibility review, route scouting, custom building blocks, non-GMP tox material and scale-up planning for research-use chemistry programs.
- Confidential target review
- Route risk ranking
- Gram-to-kilogram transition planning
- Custom pack sizes and documentation
Catalog evidence behind the platform claims
Counts and pairings below are generated from the current Data Provider snapshot.
Stereodefined cyclic dinucleotide forms
Matched (D)/(L) amidite pairs
A base appears only when both D and L records exist for the same series, protecting-group pattern and auxiliary.
| Series | DPSE pair | PSM pair |
|---|---|---|
| 2′-F | dA, dC, dG, dU | — |
| 2′-O-Me | rU | — |
| 2′-O-TBDMS | — | rA |
How to use this page
| If you need a catalog item | Start from the product catalog and search by product name, CAS number, synonym, category or application keyword. |
|---|---|
| If you need a custom structure | Send a structure, SMILES, CAS number, desired quantity, target purity, timeline and intended research-use context. |
| If you need route or scale support | Share known synthetic constraints, target scale, preferred analytical package, impurity concerns and delivery milestones. |
| If you need a technical recommendation | Describe the workflow, reaction, sequence, solvent system, assay or product family you are evaluating. |
From platform to project
Identify whether the request belongs to catalog sourcing, custom synthesis, conjugation chemistry, analytical standards or scale-up support.
Align purity, identity, salt form, pack size, analytical method, storage and documentation expectations.
Evaluate route risk, raw-material availability, purification strategy, timeline and scale assumptions.
Prepare research-use material with fit-for-purpose documentation and technical follow-up.
Start with the right entry point
Send a target structure, CAS number, desired quantity, purity target and project timeline if you want a platform-based feasibility review.
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