Technology platforms for nucleic-acid chemistry and custom research materials

Stereochemical control

Phosphorothioate stereochemistry is where oligonucleotide chemistry gets hard, and most suppliers stop at the racemate. We make the chiral reagents the stereocontrolled route runs on, and the resolved standards you need to prove the route worked.

• (D)- and (L)-DPSE and PSM amidites across the DNA, 2′-F, 2′-O-Me and 2′-O-MOE series ({chiralAmidites} in catalog)
• Resolved Rp and Sp NTPαS diastereomers for method validation ({diastereomerStandards}) — a supplier without stereocontrol cannot make these
• 2′3′-c-di-AM(PS)₂ (Rp,Rp) supplied with defined phosphorothioate configuration
• Both diastereomers of a given amidite, so a route can be run either way

Nucleoside & nucleotide chemistry

Design and preparation of protected nucleosides, modified nucleotides, NTP salts, cap-related materials and analytical standards for RNA and molecular biology workflows.

• Modified base and sugar analogs
• Triphosphate and nucleotide salt planning
• Salt form, water content and purity control
• Analytical comparison materials

Oligonucleotide building-block platform

Research-use phosphoramidites, succinates, solid-support related intermediates and specialty monomers for DNA, RNA and chemically modified oligonucleotide synthesis.

• 2′-modified RNA monomers: 2′-F, 2′-O-Me, 2′-O-MOE, 2′-O-C16 and 2′-O-C22
• Locked and bridged monomers — LNA and cEt ({lockedMonomers})
• Reverse amidites for 5′→3′ synthesis ({reverseAmidites})
• Morpholino (PMO) monomers ({pmoMonomers})
• Deprotection and compatibility review

Sulfurization & activation chemistry

Sulfurizing reagents, coupling activators and process support for phosphorothioate and solid-phase oligonucleotide synthesis workflows.

• DDTT, PADS, Beaucage-type and related sulfurizing reagents
• DCI, BTT, ETT and related activator selection
• Solubility and reaction-rate comparison
• Scale and handling assessment

GalNAc & conjugation chemistry

Ligands, linkers, clusters and conjugation-ready intermediates for delivery, labeling and functionalized oligonucleotide research.

• GalNAc ligand/linker intermediates
• Azide, alkyne, amino, thiol and maleimide handles
• PEG and spacer design
• Dye, affinity tag and payload conjugation support

Cyclic dinucleotides

STING-pathway dinucleotides in free-acid and salt forms, including the phosphorothioate versions that cannot be made without stereocontrol. {cyclicDinucleotides} in the catalog.

• 2′,3′- and 3′,3′-cGAMP, c-di-AMP, c-di-GMP, cAIMP
• Sodium, ammonium and free-acid forms of the same compound
• 2′3′-c-di-AM(PS)₂ (Rp,Rp) — the stereodefined phosphorothioate
• Made on the same amidite chemistry as the rest of the catalog

Glycochemistry

Sugar nucleotides, defined oligosaccharides and metabolic-labeling sugars for glycobiology and conjugation work. {sugars} in the catalog.

• Sugar nucleotides: UDP-Glc, UDP-Gal, UDP-GlcNAc, UDP-GalNAc, UDP-GlcA, GDP-L-Fuc, CMP-Neu5Ac
• Defined β1→3, β1→4 and α1→3/α1→4 linked di- and oligosaccharides
• GalNAz, Ac₄GalNAz and azido sugars for click chemistry
• Protected ribofuranose building blocks feeding the nucleoside routes above

mRNA raw-material platform

Materials and technical support for mRNA research workflows including cap analogs, modified nucleotides, nucleotide intermediates and analytical standards.

• Cap analog and modified NTP selection
• IVT material planning
• Research-use raw material sourcing
• Application-specific specification review

Reference, impurity & analytical standards

Defined standards to support method development, impurity identification, forced-degradation studies and lot-to-lot analytical comparison.

• Resolved Rp/Sp NTPαS diastereomers ({diastereomerStandards}) for stereochemical method validation
• Known impurity preparation
• Process marker synthesis
• LC-MS/HPLC/NMR support package
• Stability-indicating method inputs

Custom synthesis & route development

Feasibility review, route scouting, custom building blocks, non-GMP tox material and scale-up planning for research-use chemistry programs.

• Confidential target review
• Route risk ranking
• Gram-to-kilogram transition planning
• Custom pack sizes and documentation

Identify whether the request belongs to catalog sourcing, custom synthesis, conjugation chemistry, analytical standards or scale-up support.

Align purity, identity, salt form, pack size, analytical method, storage and documentation expectations.

Evaluate route risk, raw-material availability, purification strategy, timeline and scale assumptions.

Prepare research-use material with fit-for-purpose documentation and technical follow-up.