BX LAB SERVICES
Custom chemistry and development support for nucleic acid innovation
BX Lab supports research teams that need more than an off-the-shelf catalog item: custom building blocks, route development, non-GMP tox material, impurity standards and scale-ready chemistry for RNA, oligonucleotide, GalNAc and specialty nucleoside workflows.
Core services
Process development & scale-up
Route optimization, impurity control, process robustness and scale-up planning for research-use and early-development materials.
- Route selection and telescoping opportunities
- Solvent/base/reagent screening
- Impurity mapping and control strategy
- Gram-to-kilogram transition planning
Custom building blocks
Design and synthesis of nucleosides, nucleotides, phosphoramidites, linkers, GalNAc intermediates and other specialty raw materials.
- Target structure review
- Protecting-group strategy
- Catalog-adjacent analogs
- Custom pack sizes and documentation
Non-GMP tox material
Non-GMP toxicology-enabling material for preclinical evaluation, method development and formulation research where GMP manufacture is not required.
- Defined research specification
- Batch traceability
- CoA support
- Scale matched to study needs
Custom synthesis (RUO)
Research-use-only custom synthesis for novel analogs, intermediates, labeled materials and route-development targets.
- Confidential structure review
- Feasibility and lead-time estimate
- Purification and identity package
- Optional follow-on scale-up
Reference & impurity standards
Reference materials and impurity standards for analytical method development, forced-degradation studies and release-method qualification.
- Known impurity synthesis
- Process marker preparation
- LC-MS/HPLC method support
- Stability-indicating method inputs
Route scouting & feasibility
Early-stage chemistry assessment before committing to full custom synthesis or scale-up.
- Literature and route landscape review
- Risk ranking for key transformations
- Raw-material availability check
- Fast go/no-go recommendation
Analytical method support
Analytical support packages to help qualify identity, purity, residual impurities and lot-to-lot comparability.
- HPLC/UPLC method setup
- LC-MS identity confirmation
- NMR interpretation support
- CoA-ready result summaries
Conjugation & linker chemistry
Custom linker, ligand and conjugation-handle chemistry for GalNAc, lipid, dye, biotin, thiol, azide, alkyne and other functionalized materials.
- Spacer and linker selection
- Clickable or cleavable handles
- Ligand-ready intermediates
- Oligonucleotide-conjugation support
Best-fit project types
Phosphoramidites, protected nucleosides, succinates, supports, sulfurizing reagents and coupling activators.
Cap analogs, modified NTPs, nucleotide salts, intermediates and analytical standards for IVT-related research.
GalNAc ligands, lipid motifs, PEG linkers, clickable handles, fluorescent labels and affinity tags.
What to include in a request
| Target | Structure, CAS number, product name, SMILES, drawing or reference material profile. |
|---|---|
| Use case | Screening, method development, tox-enabling material, process development, reference standard or RUO custom synthesis. |
| Quantity | Desired amount, acceptable staged delivery and expected future scale. |
| Specification | Target purity, salt form, counterion, residual solvent limits, analytical method needs and documentation expectations. |
| Timeline | Requested delivery window and any critical study or campaign dates. |
How projects move forward
We review the target, risk, likely route, specification and material-use context.
You receive a practical scope with quantity, timeline, analytical package and project assumptions.
Material is prepared against the agreed research specification with fit-for-purpose analytical checks.
BX Lab provides documentation and technical follow-up for handling, storage and next-step scale-up.
Common service deliverables
Initial route assumptions, risk points and recommended next step.
Research-use material prepared to agreed specification and quantity.
Fit-for-purpose identity, purity and documentation summary based on project scope.
Recommended staged approach for larger campaigns where technically suitable.
Start a service request
Send your target, desired quantity and project context. A BX Lab scientist will review the chemistry and recommend the right path.