2'-F-ANA Phosphoramidites
5'-O-DMTr-2'-deoxy-2'-fluoro-beta-D-arabinouridine-3'-CE phosphoramidite
Quick view. A protected 2'-F-ANA uridine building block bearing a 5'-O-DMTr group and a 3'-cyanoethyl N,N-diisopropylphosphoramidite functionality. CAS 1190089-70-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-2'-deoxy-2'-fluoro-beta-D-arabinouridine-3'-CE phosphoramidite is classified as 2'-f-ana phosphoramidites (Formula C39H46FN4O8P; molecular weight 748.79).
5'-O-DMTr-2'-deoxy-2'-fluoro-beta-D-arabinouridine-3'-CE phosphoramidite — Identity-defined 2'-F-ANA-dU phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For 5'-O-DMTr-2'-deoxy-2'-fluoro-beta-D-arabinouridine-3'-CE phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-ANA-dU phosphoramidite
- 2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite
- 1-(2'-Deoxy-5'-O-DMTr-2'-fluoro-beta-D-arabinofuranosyl)uracil 3'-CE phosphoramidite
Useful catalog search terms
- CAS 1190089-70-3
Physicochemical data
| InChIKey | HQHQPAYRJJMYQX-CPBIVIIKSA-N |
|---|---|
| Nucleoside | 2'-Deoxy-2'-fluoro-beta-D-arabinouridine |
| 5' protection | DMTr |
| 3'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| MDL number | MFCD15145421 |
| PubChem CID | 99651534 |
| InChI | InChI=1S/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-24-10-22-41)52-36-33(51-37(35(36)40)43-23-21-34(45)42-38(43)46)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,42,45,46)/t33-,35+,36-,37-,53?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@H]1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMTr-2'-deoxy-2'-fluoro-beta-D-arabinouridine-3'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-deoxy-2'-fluoro-beta-D-arabinouridine-3'-CE phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FAP-0004 and CAS 1190089-70-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
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