Intermediates
2'-F-m7GDP TEA Salt
Quick view. A triethylammonium salt form of N7-methyl-2'-deoxy-2'-fluoroguanosine 5'-diphosphate. The covalent identity is resolved for CAS 956473-23-7, while exact TEA stoichiometry is unspecified. CAS 956473-23-7. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-F-m7GDP TEA Salt is classified as intermediates.
2'-F-m7GDP TEA Salt is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-F-m7GDP TEA Salt, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 2'-fluoro-7-methylguanosine diphosphate
- CAS 956473-23-7
Physicochemical data
| Covalent identity | N7-methyl-2'-deoxy-2'-fluoroguanosine 5'-diphosphate |
|---|---|
| Modification pattern | 2'-fluoro and N7-methyl |
| Salt form | Triethylammonium salt; TEA stoichiometry unspecified |
| Covalent InChIKey | AWIISYVYODHNLE-QYYRPYCUSA-N |
| Covalent InChI | InChI=1S/C11H16FN5O10P2/c1-16-3-17(8-6(16)9(19)15-11(13)14-8)10-5(12)7(18)4(26-10)2-25-29(23,24)27-28(20,21)22/h3-5,7,10,18H,2H2,1H3,(H5-,13,14,15,19,20,21,22,23,24)/t4-,5-,7-,10-/m1/s1 |
| Covalent SMILES | C[n+]1cn([C@@H]2O[C@H](COP(=O)([O-])OP(=O)(O)O)[C@@H](O)[C@H]2F)c2[nH]c(N)nc(=O)c21 |
| Canonical covalent SMILES | C[n+]1cn([C@@H]2O[C@H](COP(=O)([O-])OP(=O)(O)O)[C@@H](O)[C@H]2F)c2[nH]c(N)nc(=O)c21 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
- Cap analog selection can influence capping efficiency, orientation and downstream translation-related performance.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
- Capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
These points describe 2'-F-m7GDP TEA Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-F-m7GDP TEA Salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-INTE-0012 and CAS 956473-23-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Intermediates product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.