Succinates
DMTr-2'-MOE-G(iBu)-3'-Succinate
Quick view. DMTr-2'-MOE-G(iBu)-3'-Succinate is a protected guanosine derivative bearing 5'-O-DMTr, 2'-O-(2-methoxyethyl), N2-isobutyryl, and 3'-O-succinate groups in the free-acid form. The reviewed identity corresponds to PubChem CID 168447238. CAS 2622236-64-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2'-MOE-G(iBu)-3'-Succinate is classified as protected 2'-o-moe guanosine 3'-o-succinate (Formula C42H47N5O12; molecular weight 813.80).
DMTr-2'-MOE-G(iBu)-3'-Succinate is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For DMTr-2'-MOE-G(iBu)-3'-Succinate, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-(2-methoxyethyl)-N2-isobutyrylguanosine-3'-succinate
Useful catalog search terms
- CAS 2622236-64-8
- Succinates
Physicochemical data
| PubChem CID | 168447238 |
|---|---|
| InChIKey | CYESRKJDDOYPRE-NWKNMEOGSA-N |
| Structural features | 5'-O-DMTr; 2'-O-(2-methoxyethyl); N2-isobutyryl guanine; 3'-O-succinate; free carboxylic acid |
| InChI | InChI=1S/C42H47N5O12/c1-25(2)38(51)45-41-44-37-34(39(52)46-41)43-24-47(37)40-36(56-22-21-53-3)35(59-33(50)20-19-32(48)49)31(58-40)23-57-42(26-9-7-6-8-10-26,27-11-15-29(54-4)16-12-27)28-13-17-30(55-5)18-14-28/h6-18,24-25,31,35-36,40H,19-23H2,1-5H3,(H,48,49)(H2,44,45,46,51,52)/t31-,35-,36-,40-/m1/s1 |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OC(=O)CCC(=O)O)OCCOC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe DMTr-2'-MOE-G(iBu)-3'-Succinate or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
5'-DMTr-2'-O-MOE-rG(iBu)-3'-succinate, TEA salt
Succinates · CAS: 2622236-65-9
BX-SUCC-0002Abasic Succinate
Succinates · CAS: 1428324-58-6
BX-SUCC-0003DMTr-2'-F-dA(Bz)-3'-succinate, TEA salt
Succinates · CAS: 2504147-10-6
BX-SUCC-0004DMTr-2'-F-dC(Ac)-3'-succinate, TEA salt
Succinates · CAS: N/A
BX-SUCC-0005DMTr-2'-F-dG(iBu)-3'-succinate, TEA salt
Succinates · CAS: 1241724-83-3
BX-SUCC-0006DMTr-2'-F-dU-3'-succinate, TEA salt
Succinates · CAS: 2294880-79-6
Frequently asked questions
Can the package size for DMTr-2'-MOE-G(iBu)-3'-Succinate be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-SUCC-0024 and CAS 2622236-64-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Succinates product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.