2'-O-Propargyl Nucleosides
2'-O-propargyl-rC
Quick view. We supply 2'-O-propargyl-rC as a propargyl cytidine nucleoside for click chemistry and modified RNA probe development. CAS 206552-85-4. Catalog target purity: Specification on request.
Product profile
2'-O-propargyl-rC is classified as nucleoside or protected nucleoside intermediate (Formula C12H15N3O5; molecular weight 281.26).
2'-O-propargyl-rC can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-propargyl-rC, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 2'-O-propargyl-Cr
- 2'-O-Propargylcytidine
- Cytidine, 2'-O-2-propyn-1-yl-
- 4-Amino-1-[4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidin-2-one
Useful catalog search terms
- CAS 206552-85-4
- Nucleoside or protected nucleoside intermediate
- alkyne click handle
- 2'-O-Propargyl Nucleosides
Physicochemical data
| Key chemistry motifs | alkyne click handle |
|---|---|
| Boiling point | 544.7±60.0 °C(Predicted) |
| Density | 1.51±0.1 g/cm3(Predicted) |
| pKa | 13.24±0.70(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 2'-O-propargyl-rC or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Frequently asked questions
Can the package size for 2'-O-propargyl-rC be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0166 and CAS 206552-85-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-O-propargyl-rC or the named structural feature represented by this product.