Succinates
DMTr-2'-OMe-G(iBu)-3'-Succinate
Quick view. DMTr-2'-OMe-G(iBu)-3'-Succinate is a protected 2'-O-methylguanosine derivative bearing 5'-O-DMTr, N2-isobutyryl, and 3'-O-succinate groups in the free-acid form. The reviewed identity corresponds to PubChem CID 138376007. CAS 114745-31-2. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2'-OMe-G(iBu)-3'-Succinate is classified as protected 2'-o-methylguanosine 3'-o-succinate (Formula C40H43N5O11; molecular weight 769.80).
DMTr-2'-OMe-G(iBu)-3'-Succinate supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For DMTr-2'-OMe-G(iBu)-3'-Succinate, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-methyl-N2-isobutyrylguanosine-3'-succinate
Useful catalog search terms
- CAS 114745-31-2
- Succinates
Physicochemical data
| PubChem CID | 138376007 |
|---|---|
| InChIKey | UPTKBAGZMOVVLJ-POQUMROWSA-N |
| Structural features | 5'-O-DMTr; 2'-O-methyl; N2-isobutyryl guanine; 3'-O-succinate; free carboxylic acid |
| InChI | InChI=1S/C40H43N5O11/c1-23(2)36(49)43-39-42-35-32(37(50)44-39)41-22-45(35)38-34(53-5)33(56-31(48)20-19-30(46)47)29(55-38)21-54-40(24-9-7-6-8-10-24,25-11-15-27(51-3)16-12-25)26-13-17-28(52-4)18-14-26/h6-18,22-23,29,33-34,38H,19-21H2,1-5H3,(H,46,47)(H2,42,43,44,49,50)/t29-,33-,34-,38-/m1/s1 |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OC(=O)CCC(=O)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-OMe-G(iBu)-3'-Succinate or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-SUCC-0002Abasic Succinate
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BX-SUCC-0003DMTr-2'-F-dA(Bz)-3'-succinate, TEA salt
Succinates · CAS: 2504147-10-6
BX-SUCC-0004DMTr-2'-F-dC(Ac)-3'-succinate, TEA salt
Succinates · CAS: N/A
BX-SUCC-0005DMTr-2'-F-dG(iBu)-3'-succinate, TEA salt
Succinates · CAS: 1241724-83-3
BX-SUCC-0006DMTr-2'-F-dU-3'-succinate, TEA salt
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Frequently asked questions
Can the package size for DMTr-2'-OMe-G(iBu)-3'-Succinate be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-SUCC-0019 and CAS 114745-31-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Succinates product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.