TIPDS-protected Nucleosides
3',5'-O-TIPDS-rU
Quick view. We supply 3',5'-O-TIPDS-rU as a uridine TIPDS intermediate for regioselective 2'-hydroxyl modification and RNA analog synthesis. CAS 69304-38-7. Catalog target purity: ≥95%.
Product profile
3',5'-O-TIPDS-rU is classified as nucleoside or protected nucleoside intermediate (Formula C21H38N2O7Si; molecular weight 486.71).
3',5'-O-TIPDS-rU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3',5'-O-TIPDS-rU, reported solubility: Chloroform (Slightly), Methanol (Slightly). Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 3,5-TIPS-U
- 3',5'-TIPS-
- 3',5'-TIPS-rU
- 3',5'-TIPDS-Ur
- 3',5'-TIPS-Uridine
- 3',5'-O-TIPDS-uridine
- 3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-uridine
- 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine
Useful catalog search terms
- CAS 69304-38-7
- Nucleoside or protected nucleoside intermediate
- TIPDS protection
- TIPDS-protected Nucleosides
Physicochemical data
| Key chemistry motifs | TIPDS protection |
|---|---|
| Melting point | 90 - 92°C |
| Form | Solid |
| Color | White to Off-White |
| InChI | InChI=1S/C21H38N2O7Si2/c1-12(2)31(13(3)4)27-11-16-19(29-32(30-31,14(5)6)15(7)8)18(25)20(28-16)23-10-9-17(24)22-21(23)26/h9-10,12-16,18-20,25H,11H2,1-8H3,(H,22,24,26)/t16-,18-,19-,20-/m1/s |
| InChIKey | KKLQDUCRZCCKHG-VBSBHUPXSA-N |
| SMILES | CC(C)[Si]1(OC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC(=O)NC3=O)O)O[Si](O1)(C(C)C)C(C)C)C(C)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Related products
3',5'-O-TIPDS-2'-Spirocyclopropyl-U
TIPDS-protected Nucleosides · CAS: 140902-00-7
BX-PN-00143',5'-O-TIPDS-rA(Ac)
TIPDS-protected Nucleosides · CAS: N/A
BX-PN-00153',5'-O-TIPDS-rC(Ac)
TIPDS-protected Nucleosides · CAS: 85335-73-5
BX-PN-00163',5'-O-TIPDS-rG(Pac)
TIPDS-protected Nucleosides · CAS: 131474-72-1
Frequently asked questions
Can the package size for 3',5'-O-TIPDS-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0017 and CAS 69304-38-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the TIPDS-protected Nucleosides product family and its named chemistry.