Amino-modified Nucleosides
3'-NH₂-ddG
Quick view. A guanine nucleoside analog bearing a 3'-amino group, no 2'-hydroxyl group, and an unprotected 5'-hydroxyl group. CAS 66323-49-7. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-NH₂-ddG is classified as amino-modified nucleosides (Formula C10H14N6O3; molecular weight 266.26).
3'-NH₂-ddG provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 3'-NH₂-ddG, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 3'-Amino-2',3'-dideoxyguanosine
Useful catalog search terms
- CAS 66323-49-7
Physicochemical data
| InChIKey | HOQBPAWPBCAUGA-KVQBGUIXSA-N |
|---|---|
| Nucleobase | Guanine |
| Sugar modification | 2',3'-dideoxy with 3'-amino substitution |
| Hydroxyl state | 5' hydroxyl group unprotected |
| InChI | InChI=1S/C10H14N6O3/c11-4-1-6(19-5(4)2-17)16-3-13-7-8(16)14-10(12)15-9(7)18/h3-6,17H,1-2,11H2,(H3,12,14,15,18)/t4-,5+,6+/m0/s1 |
| SMILES | N=c1nc(O)c2ncn([C@H]3C[C@H](N)[C@@H](CO)O3)c2[nH]1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 3'-NH₂-ddG or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-NH₂-ddG be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0008 and CAS 66323-49-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.