Other Nucleosides
3'-O-Azidomethyl-2'-deoxythymidine
Quick view. 3'-O-Azidomethyl-2'-deoxythymidine is a beta-D-thymidine derivative bearing an O-CH2-N3 substituent at the 3'-oxygen and a free 5'-hydroxyl group. CAS 136041-38-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-Azidomethyl-2'-deoxythymidine is classified as other nucleosides (Formula C11H15N5O5; molecular weight 297.27).
3'-O-Azidomethyl-2'-deoxythymidine — A structurally defined 3'-O-azidomethyl deoxythymidine building block for research on modified nucleosides and preparation of related nucleotide derivatives.
For 3'-O-Azidomethyl-2'-deoxythymidine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 3'-O-Azidomethylene-dT
- 3'-O-Azidomethyl-dT
- 3'-O-N3-dT
Useful catalog search terms
- CAS 136041-38-8
Physicochemical data
| 3'-Substituent | O-CH2-N3 (azidomethyl ether) |
|---|---|
| 5'-Functionality | Hydroxyl |
| Nucleobase | Thymine |
| Sugar | beta-D-2-deoxyribofuranose |
| Glycosidic linkage | Pyrimidine N1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- The corresponding 3'-O-azidomethyl dTTP class has been reported as a chemically reversible terminator in sequencing-by-synthesis research; that literature concerns the triphosphate rather than this unphosphorylated nucleoside.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 3'-O-Azidomethyl-2'-deoxythymidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-O-Azidomethyl-2'-deoxyadenosine
Other Nucleosides · CAS: N/A
BX-NDO-00093'-O-Azidomethyl-2'-deoxycytidine
Other Nucleosides · CAS: N/A
BX-NDO-00103'-O-Azidomethyl-2'-deoxyguanosine
Other Nucleosides · CAS: N/A
BX-NDO-00137-Deaza-2'-deoxyguanosine
Other Nucleosides · CAS: 86392-75-8
BX-NDO-0014Allopurinol riboside
Other Nucleosides · CAS: 16220-07-8
Frequently asked questions
Can the package size for 3'-O-Azidomethyl-2'-deoxythymidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-NDO-0011 and CAS 136041-38-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not a BX Lab lot specification or product-performance claim.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.