Intermediates
6-Chloro-2-(trifluoromethyl)-9H-purine
Quick view. A purine intermediate bearing chloro and trifluoromethyl substituents at the 6- and 2-positions, respectively, CAS 1998-63-6. CAS 1998-63-6. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
6-Chloro-2-(trifluoromethyl)-9H-purine is classified as intermediates (Formula C6H2ClF3N4; molecular weight 222.56).
6-Chloro-2-(trifluoromethyl)-9H-purine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 6-Chloro-2-(trifluoromethyl)-9H-purine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 6-Chloro-2-(trifluoromethyl)purine
- 9H-Purine, 6-chloro-2-(trifluoromethyl)-
- MFCD08436653
- CB4156594
- AR00C44M
Useful catalog search terms
- CAS 1998-63-6
- C6H2ClF3N4
- GRFXWPMEDWAEMH-UHFFFAOYSA-N
Physicochemical data
| Heterocycle | Purine |
|---|---|
| 6-position substituent | Chloro |
| 2-position substituent | Trifluoromethyl |
| Stereochemistry | None |
| InChI | InChI=1S/C6H2ClF3N4/c7-3-2-4(12-1-11-2)14-5(13-3)6(8,9)10/h1H,(H,11,12,13,14) |
| InChIKey | GRFXWPMEDWAEMH-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1nc(Cl)c2ncnc-2[nH]1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 6-Chloro-2-(trifluoromethyl)-9H-purine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 6-Chloro-2-(trifluoromethyl)-9H-purine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-INTE-0062 and CAS 1998-63-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.