Sulfurizing Reagents
Beaucage Reagent
Quick view. A widely used sulfur-transfer reagent for converting phosphite triesters to phosphorothioate linkages on solid support. CAS 66304-01-6. Catalog target purity: Specification on request.
Product profile
Beaucage Reagent is classified as oligonucleotide sulfur-transfer reagent (Formula C7H4O3S2; molecular weight 200.23).
Beaucage Reagent — Formation of phosphorothioate linkages in automated DNA and RNA synthesis.
For Beaucage Reagent, reported solubility: soluble in Toluene. Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 3H-1,2-BENZODITHIO-3-ONE-1,1-DIOXIDE
- 3H-1,2-BENZODITHIOL-3-ONE 1,1-DIOXIDE
- 3H-1,2-BENZODITHIOL-ONE 1,1-DIOXIDE
- BSS
- 3H-1,2-BENZODITHIOLE-3-ONE-1,1-DIOXIDE(BSS)
- 3H-1,2-BENZODITHIOL-3-ONE1,1-DIOXIDE(BSS)
- 3H-1,2-BENZODITHIOL-3-ONE-1,1-DIOXIDE (BEAUCAGE REAGENT)
- Beaucage Reagent3H-1,2-Benzodithiol-3-one-1,1-diox
Useful catalog search terms
- CAS 66304-01-6
- Oligonucleotide sulfur-transfer reagent
- Sulfurizing Reagents
Physicochemical data
| Melting point | 103-107 °C(lit.) |
|---|---|
| Boiling point | 414.6±28.0 °C(Predicted) |
| Density | 1.653±0.06 g/cm3(Predicted) |
| Form | powder to crystal |
| Color | White to Almost white |
| SMILES | S1(=O)(=O)C2=CC=CC=C2C(=O)S1 |
| InChI | InChI=1S/C7H4O3S2/c8-7-5-3-1-2-4-6(5)12(9,10)11-7/h1-4H |
| InChIKey | JUDOLRSMWHVKGX-UHFFFAOYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Benchmark sulfurization chemistry for comparing alternative sulfur-transfer reagents.
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Frequently asked questions
Can the package size for Beaucage Reagent be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-SR-0003 and CAS 66304-01-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Sulfurizing Reagents product family and its named chemistry.