RNA (2'-O-TBDMS) Phosphoramidites
DMTr-2'-O-TBDMS-pseudoU-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-TBDMS-pseudoU-3'-CE-Phosphoramidite as a pseudouridine monomer for RNA synthesis. CAS 163496-23-9. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-TBDMS-pseudoU-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C45H61N4O9PSi; molecular weight 861.05).
DMTr-2'-O-TBDMS-pseudoU-3'-CE-Phosphoramidite — Pseudouridine CEP can be useful in site-selected introduction of modified purine and pyrimidine ribonucleosides into RNA by automated phosphoramidite chemistry
For DMTr-2'-O-TBDMS-pseudoU-3'-CE-Phosphoramidite, modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
Names and search terms
Confirmed or normalized name variants
- PSEUDOURIDINE CEP
- 5'-DMT-2'-O-TBDMS-Pseudouricdine-CE-Phosphoramidite
- 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-pseudouridine 3'-CE phosphoramidite
- DMT-2'-O-TBDMS-pseudoU-3'-CE-Phosphoramidite
Useful catalog search terms
- CAS 163496-23-9
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- TBDMS protection
- phosphoramidite coupling group
- RNA (2'-O-TBDMS) Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; TBDMS protection; phosphoramidite coupling group |
|---|---|
| SMILES | [C@@H]1(OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(C2C=CC(OC)=CC=2)(C2C=CC=CC=2)C2C=CC(OC)=CC=2)O[C@@H](C2C(=O)NC(=O)NC=2)[C@@H]1O[Si](C(C)(C)C)(C)C |&1:0,15,42,51,r| |
| InChIKey | JPJHNALDAAZFFN-JCWALQTNNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-O-TBDMS-pseudoU-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe DMTr-2'-O-TBDMS-pseudoU-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-TBDMS-pseudoU-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-R2OT-0021 and CAS 163496-23-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss DMTr-2'-O-TBDMS-pseudoU-3'-CE-Phosphoramidite or the named structural feature represented by this product.