DNA Phosphoramidites
DMTr-5-Me-dC(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-5-Me-dC(Bz)-3'-CE-Phosphoramidite as a modified DNA phosphoramidite for introducing functionalized or base-modified residues into synthetic oligonucleotides. CAS 105931-57-5. Catalog target purity: Specification on request.
Product profile
DMTr-5-Me-dC(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C47H54N5O9P; molecular weight 863.93).
DMTr-5-Me-dC(Bz)-3'-CE-Phosphoramidite — N4-Benzoyl-2''-deoxy-5''-O-DMT-5-methylcytidine 3''-CE phosphoramidite is used in the preparation of locked nucleic acids (LNAs) for optimization of fluorescent oligonucleotide probes with improved spectral properties and target binding.
For DMTr-5-Me-dC(Bz)-3'-CE-Phosphoramidite, reported solubility: DMSO: 250 mg/mL (294.84 mM; Need ultrasonic). Storage: Store at -20°C.
Names and search terms
Confirmed or normalized name variants
- 5-Me-dC amidite
- 5-Me-DMT-dC(Bz)-CE
- 5-Me-dCBzPhosphoramidite
- Bz-5-Me-dC phosphoramidite
- 5-Me-dC CE Phosphoramidite
- deoxy N-Bz 5-Me Cytidine Amidite
- DMT-5Me-dC(Bz)-CE Phosphoramidite
- 5-Me-DMT-dC(Bz)-CE Phosphoramidite
Useful catalog search terms
- CAS 105931-57-5
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- phosphoramidite coupling group
- DNA Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to off-white |
| SMILES | C(OC[C@H]1OC(N2C=C(C(NC(=O)C3C=CC=CC=3)=NC2=O)C)C[C@@H]1OP(=O)(OCCC#N)N(C(C)C)C(C)C)(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)C1C=CC(OC)=CC=1 |&1:3,24,r| |
| InChIKey | GURHUSQCGCDAMW-ANMPBPHANA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-5-Me-dC(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Related products
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BX-DP-0003DMTr-3'-dG(iBu)-2'-CE-Phosphoramidite
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BX-DP-0004DMTr-5-Me-dC(C6-O-Lev)-3'-CE-Phosphoramidite
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BX-DP-0005DMTr-5-[N-(naphthalen-2-ylmethyl)formamide]-dU-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-5-Me-dC(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-DP-0024 and CAS 105931-57-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DNA Phosphoramidites product family and its named chemistry.