Intermediates
Im-3'-OMe-m7GDP
Quick view. An N7-methyl-3'-O-methylguanosine 5'-diphosphate with terminal phosphoroimidazolide activation. Formula and molecular weight refer to the inner-salt identity; sodium stoichiometry is unspecified. CAS 2089461-53-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
Im-3'-OMe-m7GDP is classified as intermediates (Formula C15H21N7O10P2; molecular weight 521.32).
Im-3'-OMe-m7GDP can be evaluated in terminally blocked nucleotide, cap-chemistry and analytical-reference workflows where 3′-O-methylation changes extension or end-group reactivity.
For Im-3'-OMe-m7GDP, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- m7(3'OMeG)(5')pp-1-imidazol
- Im-m7-3'OMe-GDP
- 3'-OMe-M7-GDP-IMZ
Useful catalog search terms
- CAS 2089461-53-8
Physicochemical data
| PubChem CID | 172878658 |
|---|---|
| Parent identity | N7-methyl-3'-O-methylguanosine 5'-diphosphate phosphoroimidazolide |
| Modification pattern | N7-methyl and 3'-O-methyl |
| Activation state | 5'-diphosphate with terminal phosphoroimidazolide |
| Salt boundary | Current media uses variable sodium notation; exact stoichiometry unspecified |
| InChIKey | UYMNWTSOELIWLF-IDTAVKCVSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
- Cap analog selection can influence capping efficiency, orientation and downstream translation-related performance.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
- Capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
These points describe Im-3'-OMe-m7GDP or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for Im-3'-OMe-m7GDP be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-INTE-0022 and CAS 2089461-53-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Intermediates product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.