Isonucleosides
Pseudouridine
Quick view. We supply Pseudouridine as a naturally occurring C-glycoside uridine isomer used in RNA biology and modified RNA synthesis. CAS 1445-07-4. Catalog target purity: ≥98%.
Product profile
Pseudouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12N2O6; molecular weight 244.2).
An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations…
For Pseudouridine, reported solubility: Methanol (Very Slightly, Heated), Water (Slightly, Sonicated, Heated). Storage: Inert atmosphere,Room Temperature.
Names and search terms
Confirmed or normalized name variants
- y-Uridine
- NSC 162405
- Pseudourindine
- B-Pseudouridine
- Pseudouridine C
- 5-Ribosyluracil
- β-D-Pseudouridine
- BETA-PSEUDOURIDINE
Useful catalog search terms
- CAS 1445-07-4
- Nucleoside or protected nucleoside intermediate
- Isonucleosides
Physicochemical data
| Melting point | 222 °C |
|---|---|
| Density | 1.641±0.06 g/cm3(Predicted) |
| pKa | 8.52±0.10(Predicted) |
| Form | Solid |
| Color | White to Off-White |
| SMILES | O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O)O |&1:1,2,3,7,r| |
| InChI | InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/s |
| InChIKey | PTJWIQPHWPFNBW-IZFRNLNUNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Pseudouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe Pseudouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Frequently asked questions
Can the package size for Pseudouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0024 and CAS 1445-07-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss Pseudouridine or the named structural feature represented by this product.