Halogenated Nucleosides
2',3'-Dideoxy-3'-fluoro-5-methylcytidine
Quick view. We supply 2',3'-Dideoxy-3'-fluoro-5-methylcytidine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 115249-95-1. Catalog target purity: Specification on request.
Product profile
2',3'-Dideoxy-3'-fluoro-5-methylcytidine is classified as nucleoside or protected nucleoside intermediate (Formula C10H14FN3O3; molecular weight 243.23).
2',3'-Dideoxy-3'-fluoro-5-methylcytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2',3'-Dideoxy-3'-fluoro-5-methylcytidine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Cytidine, 2′,3′-dideoxy-3′-fluoro-5-methyl-
- 4-amino-1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one
Useful catalog search terms
- CAS 115249-95-1
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C10H14FN3O3/c1-5-3-14(10(16)13-9(5)12)8-2-6(11)7(4-15)17-8/h,6-8,15H,2,4H2,1H3,(H2,12,13,16) |
|---|---|
| InChIKey | YTMNCNXZZRCBFC-UHFFFAOYSA-N |
| SMILES | Cc1cn(C2CC(F)C(CO)O2)c(O)nc1=N |
| Melting point | 177 °C |
| Boiling point | 420.0±55.0 °C(Predicted) |
| Density | 1.60±0.1 g/cm3(Predicted) |
| pKa | 14.44±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Dideoxy-3'-fluoro-5-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-Dideoxy-3'-fluoro-5-methylcytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0157 and CAS 115249-95-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.