Halogenated Nucleosides
2',3'-Dideoxy-5-fluoro-uridine
Quick view. We supply 2',3'-Dideoxy-5-fluoro-uridine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 15379-30-3. Catalog target purity: Specification on request.
Product profile
2',3'-Dideoxy-5-fluoro-uridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11FN2O4; molecular weight 230.19).
2',3'-Dideoxy-5-fluoro-uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2',3'-Dideoxy-5-fluoro-uridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 5-Fluoro-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4(1H,3H)-dione
- Uridine, 2',3'-dideoxy-5-fluoro-
- 2’,3’-Dideoxy-5-fluoro-uridine,, FddU
Useful catalog search terms
- CAS 15379-30-3
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H11FN2O4/c10-6-3-12(9(15)11-8(6)14)7-2-1-5(4-13)16-7/h,5,7,13H,1-2,4H2,(H,11,14,15)/t5-,7+/m0/s |
|---|---|
| InChIKey | IVRKKCRUCYZZTQ-CAHLUQPWSA-N |
| SMILES | C1C[C@@H](O[C@@H]1CO)N2C=C(C(=O)NC2=O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Dideoxy-5-fluoro-uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-Dideoxy-5-fluoro-uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0173 and CAS 15379-30-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.