2'-O-Propargyl Nucleosides
2'-O-propargyl-rG
Quick view. We supply 2'-O-propargyl-rG as an alkyne-functional guanosine nucleoside for click-compatible RNA modification. CAS 206552-86-5. Catalog target purity: Specification on request.
Product profile
2'-O-propargyl-rG is classified as nucleoside or protected nucleoside intermediate (Formula C13H15N5O5; molecular weight 321.29).
2'-O-propargyl-rG can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-propargyl-rG, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Propygylguanosine
- 2’-O-(2-Propyn-1-yl)guanosine
- Guanosine, 2'-O-2-propyn-1-yl-
Useful catalog search terms
- CAS 206552-86-5
- Nucleoside or protected nucleoside intermediate
- alkyne click handle
- 2'-O-Propargyl Nucleosides
Physicochemical data
| Key chemistry motifs | alkyne click handle |
|---|---|
| Density | 1.76±0.1 g/cm3(Predicted) |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OCC#C)[C@@H]1O |
| InChI | InChI=1S/C13H15N5O5/c1-2-3-22-9-8(20)6(4-19)23-12(9)18-5-15-7-10(18)16-13(14)17-11(7)21/h,5-6,8-9,12,19-20H,3-4H2,(H3,14,16,17,21)/t6-,8-,9-,12-/m1/s |
| InChIKey | VBIXIAQUDWOPDT-WOUKDFQISA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 2'-O-propargyl-rG or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Frequently asked questions
Can the package size for 2'-O-propargyl-rG be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0164 and CAS 206552-86-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-O-propargyl-rG or the named structural feature represented by this product.