2'-O-Propargyl Nucleosides
2'-O-propargyl-rU
Quick view. We supply 2'-O-propargyl-rU as an alkyne-functional uridine nucleoside for clickable RNA modification. CAS 129778-58-1. Catalog target purity: Specification on request.
Product profile
2'-O-propargyl-rU is classified as nucleoside or protected nucleoside intermediate (Formula C12H14N2O6; molecular weight 282.25).
2'-O-propargyl-rU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-propargyl-rU, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 2'-O-propargyl-Ur
- 2'-O-Propargyluridine
- 2'-O-2-propynyluridine
- Uridine, 2'-O-2-propyn-1-yl-
Useful catalog search terms
- CAS 129778-58-1
- Nucleoside or protected nucleoside intermediate
- alkyne click handle
- 2'-O-Propargyl Nucleosides
Physicochemical data
| Key chemistry motifs | alkyne click handle |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 2'-O-propargyl-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Frequently asked questions
Can the package size for 2'-O-propargyl-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0173 and CAS 129778-58-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-O-propargyl-rU or the named structural feature represented by this product.