Halogenated Nucleosides
3'-Chloro-3'-deoxythymidine
Quick view. We supply 3'-Chloro-3'-deoxythymidine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 25526-94-7. Catalog target purity: Specification on request.
Product profile
3'-Chloro-3'-deoxythymidine is classified as nucleoside or protected nucleoside intermediate (Formula C10H13ClN2O4; molecular weight 260.67).
3'-Chloro-3'-deoxythymidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-Chloro-3'-deoxythymidine, reported solubility: DMSO (Slightly), Methanol (Slightly). Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- Zidovudine EP IMpurity B
- 3'-Deoxy-3'-chlorothymidine
- 3'-Desoxy-3'-chlor-thymidin
- Zidovudine Related CoMpound B
- Thymidine, 3'-chloro-3'-deoxy-
- Zidovudine USP Related Compound B
- 3’-Chloro-3’-deoxythymidine, ClddT
- 3’-Deoxy-3’-chloro-5-methyluridine
Useful catalog search terms
- CAS 25526-94-7
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C10H13ClN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s |
|---|---|
| InChIKey | KQVJDKGDGLWBQT-SPDVFEMOSA-N |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)Cl |
| Melting point | 180-182 °C |
| Density | 1.48±0.1 g/cm3(Predicted) |
| pKa | 9.55±0.10(Predicted) |
| Form | neat |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 3'-Chloro-3'-deoxythymidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0095 and CAS 25526-94-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.